Eight years of research were the first to develop anti-quorum sensing molecule-rich activities that block quorum sensing (microbial communication) in concentrated metabolites in noni pre-differentiated cells in a natural way without pesticides. Bacterial growth inhibition, acne inhibition, excellent reduction in sebum and pores. Regulates quorum sensing (communication between microorganisms) without the use of anti-inflammatory antibiotics superior to the steroid dexamethasone. When the amount of bacteria increases and Quormones, the language between bacteria, reaches a certain concentration (threshold), bacteria combine with each other and form biofilm, resulting in toxicity. Communication between microorganisms in the Suprastratum, a new layer of skin where microorganisms live on top of the stratum corneum, controls quorum sensing to protect against various inflammatory reactions on the skin